Aim: The purpose of this study is to determine the prevalence of mental illness in postmenopausal women. Materials & Methods: This research comprised both one hundred postmenopausal women who had gone through the menopause naturally and one hundred postmenopausal women who had not gone through surgical menopause (Post Hysterectomy). The control group consisted of individuals who were related to postmenopausal patients wherever possible. It was documented that a semi-structured performa was completed, which included information of personal identity, socio-demographic characteristics, and a detailed gynaecological and physical history. The Hamilton Anxiety Rating Scale, the Goldberg General Health Questionnaire-28, and the Beck Depression Inventory were the instruments that were used. Results: The researchers observed prior history in 15% of the study group but only 5% of the control group. In the study group, 53 people had a GHQ score of more than 4, whereas 79 people in the control group had that level. 12 people in the study group and 7 people in the control group had a mixed anxiety and depressive condition. Five people in the study group had severe depression, but none of the people in the control group did. Two people in the study group had severe depression, whereas no one in the control group did. Conclusion: According to the ICD-10, a mental diagnosis was assigned to 47% of the individuals who participated in the research group. Three percent of patients were found to be suffering from a mild form of depression, nine percent from a moderate form, and six percent from a severe kind.