Aim: To study the factors that impact the compliance with treatment in individuals diagnosed with diabetes mellitus. Material and methods: Present prospective cross-sectional study was done in the Department of general medicine, on 200 diabetes patients. All diabetes patients (both Type 1 and type 2) having age more than 18 years and who were on diabetes medication were included. Diabetes patients having age <18 years and suffering from serious complication and require hospitalization were excluded from the present study. A detailed questionnaire consisting of 25 questions which included demographic details and the questions on the reasons for the treatment interruption were given to all the patients visiting to study center. Patients responded yes or no to each of the following questions: do you have financial problem, do you have no one to accompany you for visit, is diabetes medicine available in your area, do you find sufficient time to come for visit, are you busy in family obligation, is your medication lead to side effects, are you aware about the consequences of missing the doses, do you find it good to take long life medications. Results: The factors contributing to treatment interruptions among the participants were multifaceted. Financial problems were reported by 116 participants (58.0%), indicating that cost was a significant barrier to consistent treatment. Additionally, 54 participants (27.0%) cited the absence of someone to accompany them for visits as a hindrance. The non-availability of medicines in their area affected 38 participants (19.0%), while 86 participants (43.0%) mentioned a lack of time to attend visits. Family obligations were a reason for 44 participants (22.0%), and 74 participants (37.0%) had shifted to alternative treatments. The side effects of medication were reported by 134 participants (67.0%), and 136 participants (68.0%) were not aware of the consequences of missing doses. A long-life medication period was a concern for 148 participants (74.0%), and 128 participants (64.0%) lacked awareness about the importance of taking medication. These results highlight the complex and interrelated factors that contribute to treatment interruptions in diabetes management, emphasizing the need for comprehensive support and education for patients. Conclusion: In conclusion, it is crucial to identify patients who have low adherence in order to enhance the elements that contribute to this issue. To achieve improved glycemic control among diabetes patients, it is important to enhance individual adherence to risk factors associated with poor adherence.