Background: A comparative study between application of conventional suture and stapler closure of skin in abdominal wound following surgery was undertaken to compare the merits and demerits of the techniques with the aim to study the time required for closure of surgical wound with stapler, and patients’ compliance in order to determine the better method in comparison to other. Materials and Methods: This study included a total of 60 patients with 30 of them receiving skin closure using staples and the remaining 30 receiving closure using traditional nylon sutures. The duration of wound closure, any complications after the operation, and the pain level among patients post-op were documented for both groups. Results: The present studyfound that the mean duration of time taken was less in stapler groupwith the mean duration of time takenfor stapler closure was 38.47±2.33 second and 171.29±7.52 in suture significant in Burney’s type incision.It was found that the mean duration of time taken for stapler closure was 67.95±6.38 second and 181.58±9.53 sec in suture group with statistically significantdifference in Inguinal type incision.Similarly, statistically significantdifference was present in subcoastal group with less time in stapler group. VAS score with less pain in stapler group (p<0.01). Conclusion: The use of a stapler to approximate skin edges is a better method for closing surgical woundsdue to reduced discomfort, and pain compared to the use of traditional sutures. Nevertheless, there were no noteworthy post-operative problems observed in any group.