Background: Inter-trochanteric fractures are fractures that occur in the proximal (upper) part of the femur (thigh bone), specifically between the greater and lesser trochanters. Restoring mobility safely and effectively, reducing the chance of medical problems, and getting the patient back to their pre-operative state are the objectives of treatment for any intertrochanteric fracture. Although the DHS has been demonstrated to yield positive outcomes, complications are common, especially in cases of unstable intertrochanteric fracture. One benefit of Proximal Femur Nailing fixation is that it shortens the distance between the hip joint and implant, making the construct more biomechanically stable. Aim & objectives: The present study was conducted to compare dynamic hip screw and proximal femoral nailing in inter-trochanteric fractures of the femur. Materials & Methods: The present randomised interventional study conducted on 94 cases of inter-trochanteric fractures of femur of both genders. The cases were randomly divided into 2 groups of 47 each. Group I patients were treated with dynamic hip screw and group II with proximal femoral nailing. Parameters such as type of fracture, symptoms, Harris Hip Score and complications etc. were recorded. Results: Group I had 27 males and 20 females and group II had 22 males and 25 females. Type of fracture was A1 in 22 and 25, A2 in 16 and 14 and A3 in 9 and 8 patients in group I and II respectively. Harris Hip Score was excellent in 29 and 35, good in 12 and 8, fair in 5 and 4 and poor in 1 and 0 patients in group I and II respectively. Complications were hematoma in 3 and 2, prolonged drainage in 2 and 1, superficial infection in 1 and 2 and implant failure in 2 and 0 patients in group I and II respectively. The difference was significant (P< 0.05). Conclusion: Proximal femoral nailing as compared to dynamic hip screw in inter-trochanteric fractures of the femur exhibited superior results.