With the invention of the modern advanced telescopes, cold xenon light source, multiple dual-trocars, automatic gas insufflators and various instruments, especially the development of the chip cameras which helped in monitoring the procedure on a monitor in 1986, Laparoscopy has become more widely accepted. The study was conducted on total of 150 patients who underwent Laparoscopic cholecystectomy. The study assigned to study the efficacy of local infiltration of bupivacaine in controlling postoperative port site pain vs. conventional analgesics following laparoscopic cholecystectomy. Out of the total 75 patients who received port site Bupivacaine (test) 67 of them (87%) reported only a mild pain and 5 of them reported moderate pain and only 3(9.7%) of them reported severe pain when compared to non-bupivacaine group (control) in which 10 of them reported mild pain and 37 patients reported moderate pain and 28 (90.3%) reported severe post-operative pain,. The Visual Analogue scale at 24 hours showed that those received port site Bupivacaine reported statistically significant (p<0.001) lower pain.