Surgical wound site infection is one of the most commonly occurring complications in daily practice. Incidence of post-operative wound site infection has been lowest in clean surgical cases. Prophylactic antibiotics are routinely used in all surgical cases. But, this is not indicated in many such clean surgical cases. A comparative study of a total of 100 Patients undergoing elective clean surgeries. Data was collected by meticulous history taking, careful clinical examination appropriate hematological and microbiological investigations and follow up of the cases as planned according to the proforma prepared for the study intended. Among all the 100 cases, male patients were operated in large number with male to female ratio of 3:2 with majority of inguinal hernias (28%) and least with ear repairs (4%). Two cases (4%) in each group had post-operative infections noticed on the day 2 wound examination. All the four cases had culture positive with isolates being S aureus in three cases and E coli in single case.