Background: Laparoscopic cholecystectomy, a minimally invasive procedure to remove the gallbladder, requires secure sealing of the cystic artery to prevent bleeding. The present study was conducted to compare liga clips and bipolar diathermy for cystic artery sealing in laparoscopic cholecystectomy. Materials & Methods: The study was conducted at PMCH Patna, Bihar from August 2021 to August 2023. 76 patients diagnosed with gallbladder disease and scheduled for laparoscopic cholecystectomy were divided into 2 groups of 38 each. Group I patients underwent laparoscopic cholecystectomy with the use of bipolar diathermy for sealing the cystic artery, while group II patients underwent laparoscopic cholecystectomy with the application of nonabsorbable Liga clips for sealing the cystic artery. Parameters such as operative time (in mins), intra operative drain volume (ml), immediately drain volume (ml), drain volume on day 1 and day 5, post- op bleeding and mortality etc. was recorded. Results: Group I had 18 males and 20 females and group II had 19 males and 21 females. In group I and group II, GB injury was seen in 5 and 2, cystic duct injury in 1 and 0 respectively. The mean operative time (in mins) was 51.2 and 57.5, intra operative drain volume (ml) was 46.2 and 45.1, immediately drain volume (ml) was 35.8 and 36.2, drain volume on day 1 was 23.1ml and 23.0ml and drain volume on day 5 was 14.2ml and 14.7 ml. The difference was significant (P< 0.05). Post- operative bleeding was seen in 1 in group I only. The difference was non- significant (P> 0.05). Conclusion: In terms of overall results, post-operative morbidity, and mortality, bipolar cautery is a safe substitute for clipping when it comes to sealing the cystic artery.Bipolar cautery is an economical, dependable, and successful way to treat the cystic artery.