Background: Tropical fevers are defined as infections that are prevalent to tropical or subtropicalregions. DuringCovid‐19 pandemic, risk of other tropical fevers was increased. Mostpeople with these co-infections had mild illness. However, both tropical fevers and COVID-19can cause severe illness that can result in death.Due to clinical similarities to COVID-19, tthis retrospective study was conducted to investigate the role of co-infection on the clinical andhematology profile and outcome of COVID-19 patients. Material & method: For this purposea retrospective study has been conducted in Dayanand Medical college andHospital, Ludhianaenrolled patients admitted during from June 15 to October15, 2022.A totalof confirmed 20 patients of co-infections. Out of total suspected Covid patients admitted to theEmergency of thehospital wereenrolled.Data of Throat swab, nasopharyngeal swab andblood sample from suspected patients werecollected. All swab samples were tested fortheconfirmation of SARS-CoV-2.Based upon hematologychanges, further sample for serologytesting of tropical infections were sent. Results: Out of all suspected patients admitted in emergency, SARS COVID 19 was found to be positive in 523 patients and co-infection with tropical fever was seen in 20 patients.Co-infection withDenguewas seen in 20 cases, Leptospira in 2 cases and scrub typhus in 1case. Fever was present in all 20 cases. Thrombocytopenia was present in all 20 cases. Out of20 cases 17 got discharged and 3 got expired. Conclusion: A detailed analysis of disease onset, symptoms, signs, warning signs and lab values will help us to diagnose co-infections early and it will significantly affect our choice of treatment and improve the outcome.