Background:Acute stroke is the acute onset of focal neurological deficits in a vascular territory affecting the brain, retina, or spinal cord due to underlying cerebrovascular diseases.Hence, the present study was conducted to analyzeserum lipid profile as risk factor for development of ischemic stroke.Materials &Methods:200 patients were enrolled who had suffered an ischemic stroke and 200 control patients who had come for a standard physical examination. All of the patients' clinical and demographic information was gathered. A brain CT scan was used to confirm the stroke diagnosis. On the day of admission, a 12-hour fast was followed by a lipid profile. It was considered typical to have serum total cholesterol less than 200 mg/dl, LDL cholesterol less than 100 mg/dl, triglycerides fewer than 150 mg/dl, and HDL higher than 40 mg/dl. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results:A total of 200 patients were of ischemic stroke group and 200 were of control group. The mean age of the patients of the Ischemic stroke group and control group was 53.2 years and 50.7 years respectively. Abnormal TG, TC, LDL and HDL was present in 26 percent, 30.5 percent, 72.5 percent and 50.5 percent of the patients respectively of the ischemic stroke group and in 12 percent, 18 percent, 15 percent and 14 percent of the patients respectively of the control group. While analyzing statistically, significantly higher abnormal lipid profile was seen in ischemic stroke group.Conclusion:Lipid profile was a significant risk factor for occurrence of ischemic stroke. To better understand the other potential risk factors associated with the occurrence of ischemic stroke in India, more research is required.