Background: Globally, breast cancer is the most prevalent cancer type among women. The present study assessed histomorphological spectrum of breast lesions in young females. Materials & Methods: 65 females with breast lesions were enrolled. Breast trucut biopsies, needle core biopsies, excisional biopsies, and mastectomy specimens were obtained. Standard techniques were used for the histopathological evaluation, which included 10% formalin, paraffin embedding, and H&E staining. Results: Benign breast lesions found to be fibrocystic breast disease in 4, fibroadenoma breast in 7, fibroadenomatosis in 6, benign breast lesion in 12, breast abscess in 10, proliferative breast disease without atypia in 7, benign fibrous histiocytoma in 4, tubular adenoma in 3, accessory breast in 1, lipoma in 5, and granulomatous lesion in 1 case. The difference was significant (P< 0.05). Malignant lesions were invasive ductal carcinoma breast in 3 and proliferative breast disease with atypia in 2 cases. The difference was non- significant (P> 0.05. The site of breast lesion was upper outer Quadrant in 25, lower Outer Quadrant in 10, Upper Inner Quadrant in 7, Lower Inner Quadrant in 8, Central Quadrant in 6 and Whole Quadrant in 9cases. The difference was significant (P< 0.05). Conclusion: The majority of cases had benign lesions rather than malignant ones. Benign breast lesions and breast abscesses were frequent lesions. The upper outer quadrant was a common site.