Background: Breast cancer remains a significant health concern worldwide, with its incidence rising due to various factors, including urbanization and lifestyle changes. Understanding the risk factors, both reproductive and lifestyle-related, is crucial for early detection and prevention. Methods: A retrospective case-control study was conducted at a hospital with 69 histopathologically confirmed breast cancer cases and 69 controls. Cases and controls were matched by age (±3 years). Data were collected on sociodemographic, reproductive, and other risk factors, analyzed using Chi-square tests, Odds Ratios (OR), and Fisher's exact test. Results: Urban residence (OR=1.27, 95% CI=0.78–2.0, p=0.599) and education level (OR=1.03, 95% CI=0.63–1.6, p=0.861) were not significantly associated with breast cancer. Higher risk was observed for late age at first childbirth (>25 years) (OR=2.80, 95% CI=1.13–6.95, p=0.070), shorter breastfeeding duration (≤2 years) (OR=2.88, 95% CI=1.09–7.6, p=0.116), and history of abortions (OR=3.35, 95% CI=1.37–8.18, p=0.052). Comorbidities (OR=2.27, 95% CI=1.25–4.11, p=0.039) and tobacco use (OR=2.11, 95% CI=1.09–4.09, p=0.110) also showed higher risks. Conclusion: The study identified significant reproductive and lifestyle risk factors for breast cancer. Early first childbirth, prolonged breastfeeding, and avoiding abortions may reduce risk. Additionally, managing comorbidities and tobacco consumption is crucial. Increased awareness and education about modifiable risk factors are essential for breast cancer prevention in developing countries like India.