Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality globally, with oxidative stress and inflammation playing key roles in its pathogenesis. Elevated serum uric acid levels have been linked to these processes. This study investigates the serum uric acid levels in COPD patients and their correlation with disease severity. Methods: A cross-sectional study was conducted at Coimbatore Medical College and Hospital from July 2021 to June 2022. The study included 100 COPD patients. Serum uric acid levels were measured, and patient characteristics such as age, sex, duration of disease, place of residence, and BMI were recorded. Result: Mean uric acid levels were higher in patients with a disease duration of >10 years (8.154 mg/dL) compared to those with 0-5 years (7.05 mg/dL) (p=0.002). No significant differences were found in uric acid levels based on age (p=0.651), sex (p=0.176), place of residence (p=0.272), or BMI (p=0.130). Conclusion: Serum uric acid levels significantly correlate with the duration of COPD, suggesting its potential as a marker for disease severity. Further research is warranted to explore therapeutic interventions targeting uric acid levels