Background:Lower back pain (LBP) is one of the most common presenting complaints globally. The intervertebral discs consist of an inner nucleus pulposus (NP), outer annulus fibrosus (AF), and the cartilaginous endplates that anchor the disc to its vertebras.This study was conducted for the comparison of caudal, transforaminal and interlaminar routes in management of lumbar prolapsed intervertebral disc.Materials and Methods: This study comprised of 90 subjects with lumbar prolapsed intervertebral disc. The subjects had been informed about the procedure and were asked for consent. The subjects who were willing to participate and give consent had been included in the study while those who were not willing to give consent and participate had been excluded. The subjects were managed through caudal, transforaminal and interlaminar routes and the comparison of the three routes was carried out. The subjects had been divided into three groups based on these routes as group 1,2 and 3 respectively. Statistical analysis had been conducted using SPSS software.Results:There was total 36 males and 54 females in this study. Group 1 had 14 males and 16 females. Group 2 had 12 males and 18 females whereas Group 3 had 10 males and 20 females. The highest average score had been observed at 6 months after injection for all three groups. Also, the transforaminal group showed the best outcomes with 28 patients showing excellent, 32 showing good, 20 showing fair and 10 showing poor rate of improvement.Conclusion: The highest average score had been observed at 6-month after injection for all three groups. Also, the transforaminal group showed the best outcomes with 28 patients showing excellent, 32 showing good, 20 showing fair and 10 showing poor rate of improvement.