Aim: To evaluate the relationship between complex regional pain syndrome and the procedure used to reduce a fracture in the distal radius. Material and Methods: The current investigation included a sample of 120 patients, including individuals of both male and female genders, who had sustained distal radius fractures. Prior to the study, all participants were provided with information on the research and their explicit consent was collected in writing. Demographic information, including age, gender, and other pertinent data, was documented for each patient. Every patient had a comprehensive clinical and physical evaluation. The patients were categorized into two groups according to the occurrence of Complex Regional Pain Syndrome (CRPS): Group I consists of patients who have been diagnosed with Complex Regional Pain Syndrome (CRPS), whereas Group II comprises patients who do not have CRPS. Results: Group I, which includes 35 people, is classified as CRPS. Group II, on the other hand, consists of 85 individuals and does not have CRPS. Closed reduction was performed on 15 people, which accounted for 42.9% of Group I . There were 55 patients (64.7%) in Group II. The p-value is 0.02, indicating statistical significance.Open Reduction was performed in Group I on 20 patients (57.1%). There were 30 patients (35.3%) in Group II.The use of an external fixator was performed on 10 and 23 patients in group I and II, respectively. In group I, 12 and 28 patients had ulnar fractures, while in group II, 13 and 34 patients had open fractures. The disparity was statistically significant (P< 0.05).The risk variables for CRPS were the average age in years, the manner of reduction, and the presence of ulnar fracture and open fracture (P< 0.05). Conclusion: The research found that the technique used to realign broken bones (fracture reduction) is a major factor that increases the chance of developing Complex Regional Pain Syndrome (CRPS) in individuals with fractures in the distal radius. More precisely, patients who received open reduction had a greater probability of acquiring Complex Regional Pain Syndrome (CRPS) in comparison to those who had closed reduction. Additional study is required to investigate more risk factors and devise preventative measures for CRPS in this specific group of patients.