Background: Percutaneous Transhepatic Biliary Drainage (PTBD) is a crucial intervention for managing obstructive jaundice. This case series examines the effectiveness of PTBD using a central line in improving bilirubin levels in 50 patients. Materials &Methods: This retrospective case series included 50 patients who underwent PTBD with a central line. A central line was inserted into the biliary system to facilitate drainage. Bilirubin levels were measured before the procedure and at follow-up intervals (1 week, 2 weeks, 1 month). Improvements were analyzed. Results:Mean total bilirubin levels at Baseline, Post- procedural 1 week, Post- procedural 2 weeks and Post- procedural 1 month was 12.9 mg/dL, 8.1 mg/dL, 7.2 mg/dL and 5.3 mg/dL respectively. Significant results were obtained while comparing bilirubin levels at different time intervals. Complications were seen in 9 patients (18 percent). Out of these 9 patients, minor complications were seen in 7 patients while major complications were seen in 2 patients. Conclusion:PTBD using a central line is an effective method for reducing bilirubin levels in patients with obstructive jaundice.