Introduction:Solitary Thyroid nodule presents a challenge in s diagnosis, evaluation and management. Often these abnormal growths/lumps are large in size and develop at the edge of the thyroid gland, so that they are felt or seen as a lump in front of the neck. The ultimate aim in the study of solitary nodule of thyroid (SNT) is to find out the incidence of malignancy. Methodology: Hospital based prospective study. The present study is carried out in Department of General Surgery at Siddhartha medical college. With 80 samples over a time period of one year. Inclusion Criteria: 1. Patients admitted in general surgery department with solitary nodule during the period of study will be included. 2. All the patients of age more than 13 years. 3. Both sex are included. Statistical analysis was done by spreading the data over excel sheet using EpiInfo software. Results: 80 cases were included in the study, out of which 73 cases (91.25%) were females while 7 cases (8.75%) were male and female to male ratio was 10.42:1. Nodules predominantly presented in right side i.e., 62.5%. Conclusion: Incidence of Malignancy of solitary thyroid nodule was 7.50% as compare to benign incidence. Complications of STN, 8.75% cases of STN became toxic and 7.5% cases turned into malignancy. Hemi thyroidectomy was commonly performed on all the cases.