Irrational use and prescription pattern of antibiotics are among the major causes of increasing rate of development of their resistance. Most of the developing countries have constituted strict guidelines regarding prescribing and usage of antibiotics to combat a serious issue like antibiotic resistance. WHO has given guidelines for appropriate use of available antimicrobial drugs. This study was taken to evaluate the pattern of use of antibiotics in elective surgeries in the department of General Surgery of D.Y Patil Hospital and Research Institute to analyze the depth of rationality regarding their usage. Total 50 patients undergoing elective surgeries were taken to complete this study. Data were figured out under various aspects & those aspects are: (a) Gender wise distribution of the patients, (b) Age wise distribution of the patients, (c) Distribution of the patients according to age group & gender, (d) Usage of group of antibiotics according to system wise surgeries. (e) Usage of group of antibiotics according to operative period. (f) Usage of group of antibiotics according to route of administration, (g) Usage of antibiotics in different strengths and dosage forms, (h) Usage of antibiotics in different frequencies. Following observations were made from the obtained result :- (1) Half of the admissions were observed in the geriatric age group and were lowest in the age group of less than 20 years. (2) Almost equal numbers of male and female patients were admitted. (3) The most commonly used antibiotics are Cefotaxime & Amoxicillin. (4) In case of requirement of the 2nd antimicrobial, metronidazole and Piperacillin Tazobactam combination were used. (5) In pre and post operative period there was no change in frequency. But in pre operative period duration of use of antibiotics was mostly 2-3 days, whereas in post operative period duration range was from 5-10 days. (6) In preoperative period for long surgeries, surgery department administered all antibiotics twice daily, but in case of small surgeries single dose of antibiotics was preferred as prophylaxis. (7) Patients who were less than 20 years of age were given cefotaxime in 500mg strength. (8) The preferred route for giving surgical prophylaxis in elective surgeries was parenteral.