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Volume 13 Issue 5 (May) 2024

Original Articles

Evaluating the serum uric acid levels, serum lipid profiles and blood pressure in patients with essential hypertension compared to healthy controls
Monica R Dixit, Kanika Mishra, Ranjan Kumar Dixit, Ashish Kumar Sharma, Pallavi Anand, Sudhir B Mishra

Aim: This study aims to evaluate the serum uric acid levels, lipid profile, and blood pressure in patients with essential hypertension compared to healthy controls. Material and methods: A cross-sectional analysis was conducted involving two groups: hypertensive patients (n = 50) and age- and sex-matched healthy controls (n = 50). Blood pressure was measured using an OMRON automatic blood pressure monitor after subjects had rested in a seated position for at least 10 minutes. The sera was used for analysis of serum uric acid by Uricase-Peroxidase Method using ERBA CHEM – 5 PLUS SEMIAUTO ANALYZER, Triglycerides (TG) by Glycerol-3-Phosphate method, Total cholesterol (TC) by CHOD-PAP method, High Density lipoprotein (HDL) by DIRECT method, low density lipoprotein (LDL) by FRIEDEWALD EQUATION and very low density lipoprotein (VLDL) by FRIEDEWALD EQUATION. Results: Demonstrated that patients with essential hypertension exhibited significantly higher serum uric acid levels (p < 0.001), elevated lipid profiles, including total cholesterol, low-density lipoprotein (LDL), and triglycerides (p < 0.001), and increased systolic and diastolic blood pressure (p < 0.001) compared to healthy controls. Conclusion: These findings suggest a strong association between essential hypertension and metabolic disturbances, highlighting the need for comprehensive cardiovascular risk management in hypertensive patients. Further research is warranted to explore the underlying mechanisms and potential therapeutic interventions targeting these metabolic parameters.

 
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