Background: This study was a Retrospective Clinical Analysis of Epilepsy Treatment for Children with Drug-Resistant Epilepsy Material and methods: Data from 100 DRE subjects were examined. The following were the inclusion criteria for patients: (1) belonged to the age range of 1 to 14 years; (2) had uncontrollably occurring seizures with the use of an AED and adrenocorticotropic hormone therapy; (3) had undergone tests using MRI, CT, and VEEG; (4) follow-up data were available; and (5) guardians provided informed consent. Exclusion criteria included: (1) benign epilepsy syndromes in children, such as benign occipital epilepsy, benign childhood epilepsy with centro-temporal spikes, and other syndromes better managed with AEDs; (2) unclear recurrence of seizures or incomplete removal of epileptogenic foci (Figure 1); (3) patients with a history of surgical resection. Statistical analysis was conducted using SPS software. Results: In this study of 100 subjects, there were 50 males and 50 females. Generalized tonic seizures were seen in 39 subjects, complex partial motor type was seen in 27 subjects, generalized tonic-clonic seizures were seen in 17 subjects and simple partial motor seizures were seen in 16 subjects. 40 subjects with epilepsy were treated by medication, 35 as well as 25 subjects had been managed with resection surgery as well as palliative surgery, respectively.Favourable seizure outcomes had been noticed among 10, 25, and 15subjects on medication, resection surgery, as well as palliative groups, after 1-year follow-up; 8, 21, and 10 subjects after 3-year follow-up; 6, 17, and 9 subjects after 5-year follow-up. Conclusion:Children's growth and cognitive ability were negatively impacted by recurrent seizures. Preventing mental retardation and controlling seizures could both benefit from early surgical intervention. Patients who were not good candidates for resection surgery might potentially consider palliative surgery.