Introduction: Acinetobacter baumannii (A. baumannii)is a gram negative bacillus andmortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. The increasing antimicrobial resistance makes the treatment options available very limited necessitating the need for a continuous Antimicrobial Resistance surveillance that would aid in the proper implementation of the empirical therapy while taking into consideration its extensive antibiotic resistance spectrum. Objectives: This study aims to determine the prevalence & antibiotic resistance pattern of A. baumannii isolated from the CSF samples from the post neurosurgical cases. Material and methods: A cross-sectional study was conducted over two years, from December 2021 to November 2023, at the Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar. Data from 28 patients with positive CSF samples for A. baumannii were collected, including age, gender, antimicrobial susceptibility, and mortality. CSF samples were received in culture bottles and incubated in the BacT/ALERT system. Positive bottles underwent gram staining and subcultures on blood, MacConkey agar, and Chocolate agar. Non-lactose fermenter colonies were identified using VITEK Densichek, and antimicrobial susceptibility testing was conducted using the using the VITEK 2 ID-GNB card and AST-NO09 card respectively in VITEK 2 system with software release 2.01. Results: Mean age of the patients with Acinetobacter meningitis included in this study was 32.2 years. 16/28 (57.1%) were male. All cases were associated with previous neurosurgical procedures. Of the total number of patients enrolled in the study, 11 patients had MDR isolates whereas 2 patients had XDR Acinetobacter. 19 (67.8%) and 25 (89.2%) of the isolates were resistant to Imipenem and Meropenem respectively. Mortality rate of the patients was 60.7%. Conclusion: In critically ill patients post-neurosurgery, A. baumannii infection poses a significant challenge. Understanding the pattern and antibiotic susceptibility of Acinetobacter meningitis is crucial for effective antimicrobial strategies, reducing mortality and morbidity. Continued efforts are required to develop improved antimicrobial policies and implement effective infection control practices. Given the high mortality rates observed, aggressive empirical treatment, including intrathecal therapy, is necessary in regions with endemic meningitis.