Background:Misoprostol is a medication that belongs to the prostaglandin analog class, specifically prostaglandin E1 (PGE1). It is commonly used in gynecology and obstetrics for various purposes, including cervical ripening, induction of labor, and prevention of postpartum hemorrhage.The present study was conducted to evaluate effect of misoprostol before hysteroscopic polypectomy. Materials & Methods:58 women complaining from vaginal bleeding and diagnosed to have an endometrial polypwere divided into two groups of 29 each. In group I, subjects received two 400 mcgvaginal misoprostol tablets 6 hours before the procedure and group II women who did not receive misoprostol before hysteroscopy. The duration required for cervical dilatation up to Hegar number 8 was the study's key outcome measure. The surgical time, complications during cervical dilatation, and adverse effects were recorded. Results: Parity 0 was seen in 14 and 11, 1 in 6 and 6, 2 in 5 and 6, 3 in 3 and 4 and 4 in 1 and 2 subjects in group I and II respectively. Gravidity 0 seen in 12 and 13, 1 in 4 and 5, 2 in 5 and 3, 3 in 4 and 6 and 4 in 4 and 2 subjects in group I and II respectively. The difference was non- significant (P> 0.05). The mean dilatation time in group I subjects was 91.4 seconds and in group II subjects was 115.2 seconds. The mean operative time in group I subjects was 184.8 seconds and in group II subjects was 236.4 seconds. The difference was significant (P< 0.05). Complications such as false passage was seen in 2 subjects in group II and cervical lacerations in 4 subjects in group II. There were no such complications in group I subjects. The difference was significant (P< 0.05). Conclusion: Cervical primiing can be achieved in a straightforward, safe, and efficient manner by using a regimen of 400 mcg vaginal misoprostol given six hours before to hysteroscopic polypectomy. This will shorten the duration of the procedure and reduce the need for cervical dilatation and problems.