Background: Comparison between the Fine Needle Non-Aspiration Cytology (FNNAC) and Fine Needle Aspiration Cytology (FNAC) in acquiring ultrasound-guided fine needle cytology (FNC) samples from solid thyroid nodules to determine the better technique, hence improving the sample quality aiming to decrease the number of unnecessary thyroidectomy operations. Result: Prospective study showed statistically significant increase in cellular yield, preservation of cellular architecture and decrease in cellular trauma along with statistically significant increase in total sample quality with FNNAC (P value = 0.32, 0.004, 0.011, 0.21 respectively), and statistically insignificant difference in background blood in the sample (P value = 0.8).Regarding sample convenience, FNNAC demonstrated higher cellular yield, less cellular trauma, and better preservation of cellular architecture compared to FNAC. The total sample quality score was significantly higher with FNNAC. Diagnostically superior samples were obtained more frequently with FNNAC, while FNAC acquired more diagnostically adequate samples. Non-diagnostic samples were less common with FNNAC. Conclusion: FNC is an approved sensitive and cost-effective method to evaluate thyroid nodules, FNNAC technique was found to be more convenient for both the patient and the operator with statistically significant improvement in total sample quality compared to FNAC.