Background: Endotracheal intubation is an essential skill to secure a patient’s airway as well as provide oxygenation and ventilation. Dexmedetomidine is suitable for sedation and analgesia during the whole perioperative period. Clonidine is an imidazoline compound that has been extensively studied. Hence; the present study was undertaken for comparing the efficacy of ivdexmedetomidine and iv clonidine to attenuate stress response to laryngoscopy and endotracheal intubation. Materials & methods: A total of 150 subjects of ASA Grade I/II were enrolled. All the subjects were randomized into three study groups as follows: dexmedetomidine group (Received IV dexmedetomidine 1 μg/kg in 100 ml NS over 10 min), Clonidine group (Received IV clonidine 2 μg/kg in 100 mL NS over 10 min) and control group (Received 100 mL of NS over 10 min). Pre-anesthetic evaluation of all the patients was done one day before the surgery. Complete demographic and clinical details of all the subjects was recorded. Intra-operative hemodynamic variables were recorded at 1 min, 3 min, 5 min, and 10 min after laryngoscopy and intubation. Surgery was commenced 10 min after laryngoscopy and intubation. Results: Mean age of the patients of dexmedetomidine group, Clonidine group and Control group was 33.8 years, 31.9 years and 30.6 years respectively. Mean SBP, DBP and MAP among the patients the patients of dexmedetomidine group were significantly lower in comparison to the patients of the clonidine group and control group at different time intervals. Conclusion: Both dexmedetomidine and clonidine were effective in attenuation of the hemodynamic response to intubation. However; among clonidine and dexmedetomidine, dexmedetomidine is more effective.