Background:Women with high-risk pregnancies often experience significant psychological distress due to a variety of factors.The present study was conducted to evaluate depressive symptoms and psychological distress women with high-risk pregnancy. Materials & Methods:82 women with high-risk pregnancy reporting to psychiatric department with depressive symptoms and psychological distress were selected and their Edinburgh Postnatal Depression Scale (EPDS) and Brief Symptom Inventory 53-items (BSI-53) in antenatal period (Phase 1) was recorded. In the second phase, EPDS, BSI-53, and the posttraumatic stress disorder (PTSD) scale was recorded in postpartum period (Phase 2). Results: The mean gestational age in phase 1 was 29.4 weeks and in phase 2 was 30.6 weeks, parity was 2.07 in phase 1 and 2.29 in phase 2, depression score (EPDS) was 7.5 in phase 1 and 7.1 in phase 2, total BSI-53 was 32.8 in phase 1 and 39.8 in phase 2 and GSI was 0.73 in phase 1 and 0.84 in phase 2. Depressive symptoms was seen in 16 and 56 and psychological symptoms in 25 and 47 in phase 1 and phase 2 respectively. Antenatal and postnatal period, mean depression score (EPDS) was 7.61 and 24.7, BSI-53 Somatization was 3.6 and 4.2, obsession-compulsion was 2.8 and 4.4, interpersonal sensitivity was 2.3 and 3.8, depression was 3.9 and 4.2, anxiety was 3.1and 4.1, hostility was 2.7 and 2.5, phobicwas 2.5 and 2.8, paranoid ideation was 2.1 and 4.0, psychoticism was 1.8 and 3.9, total BSI-53 was 24.7 and 31.6, and GSI was 0.76 and 1.7 respectively. The difference was significant (P< 0.05). Conclusion: The prevalence and persistence of postnatal depression in women with high-risk pregnancy found to be high.