Aim: The aim of the present study was to assess the treatment success in patients with unilateral ISSNHL and to study the factors associated with the treatment outcome. Methods: This prospective observational study included 31 patients with unilateral ISSNHL admitted in the Department of Otorhinolaryngology, Government Medical College, Thiruvananthapuram from January 2019 to June 2020. Patients were given high dose intravenous methylprednisolone for 2 days followed by salvage intratympanic dexamethasone therapy weekly up to a maximum of 3 doses. Patients were also given acyclovir. A semi structured proforma was used to gather the required information. Repeated pure tone audiograms were done till 3 months. Results: In this study of 31 patients, 13 patients (41.9%) achieved recovery, out of which 11 patients (35.5%) had complete recovery and 2 patients (6.5%) had partial recovery. Female gender (p=0.027) and upper or upper middle socioeconomic groups (p=0.008) were found to be good prognostic indicators. Patients with mild, moderate and moderately severe hearing loss had significantly better outcomes than severe and profound hearing loss (p=0.007).Five patients with an up-sloping audiometric configuration had complete recovery, a statistically significant finding (p=0.0076). Seven patients presented after one week and none of them recovered (p=0.074). Conclusion: Systemic steroids with salvage intratympanic steroids is the most accepted treatment option in ISSNHL. 41.9% patients benefitted from the treatment given. Patients with mild, moderate and moderately severe hearing loss had better outcomes than severe and profound hearing loss. Patients with up sloping audiogram had better recovery than those with down sloping or flat audiogram. Female gender and higher socioeconomic status were found to have good outcome whereas, patients with dyslipidemia had poor recovery.