Background:Necrotizing fasciitis (NF) is a life-threatening soft tissue infection characterized by rapid tissue necrosis and systemic toxicity. Early recognition and aggressive management are crucial for improving patient outcomes; however, the clinical patterns and prognostic factors of NF remain poorly understood.Methods:A retrospective observational study was conducted at Government Medical College Tiruppur, analyzing the medical records of 77 patients with features suggestive of NF admitted between May 2021 and December 2023. Demographic characteristics, clinical presentation, outcomes, and associated risk factors were analyzed. Statistical analysis was performed to identify factors associated with morbidity and mortality in NF patients.Result:Among the study cohort, predominantly female (68.83%) patients with a mean age of 62.22 years were observed. Swelling of limbs was the most common presenting feature (73.68%), with a mortality rate of 18.18%. Diabetes mellitus (68.83%) and trauma (15.79%) were significant risk factors associated with adverse outcomes (p < 0.05).Conclusion:NF remains a formidable challenge with significant morbidity and mortality. Early recognition, aggressive management, and identification of risk factors such as diabetes mellitus and trauma are crucial for improving patient outcomes.