Background:Surgical site infections (SSIs) are responsible for about 20% of all healthcare-associated infections (HAIs) and at least 5% of patients undergoing a surgical procedure develop a surgical site infection. Hence, the present study was conducted for evaluating incidence and risk factors surgical site infections.Materials &Methods:A total of 500 subjects who underwent surgical procedures were enrolled. Complete demographic and clinical details of all the patients were obtained. Follow-up of all the patients was done and incidence of surgical site infection was evaluated. The definition of SSI used for the diagnosis of infection by the medical team responsible for patient follow-up during hospitalization is the National Healthcare Safety Network (NHSN) definition. Logistic regression model was used to analyze the association between the independent variables with SSI. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results:SSI was found to be present in 17.2 percent of the patients. Age of more than 60 years, Mean duration of surgery of more than 120 minutes, Length of hospital stay of more than 48 hours, ASA grade of more than II, operated under general anesthesia and Emergency surgery were found to be significant risk factors for occurrence of SSI.Conclusion: Early identification of SSI risk is crucial for patients undergoing general surgery, since it enables the adoption of preventative interventions aimed at lowering infection rates.