Background: Diabetes mellitus and hypothyroidism is a group of endocrine diseases that causes cardiovascular complications. The level lipid profile is an important diagnostic tool that is used to predict coronary artery diseasesin hypothyroid with type II diabetes patients.This study focuses on reducing the lipid profile level during diabetes and hypothyroidism with cardiovascular complications. Materials and methods:100 samples were taken and divided into four groups with control. 25 cases of hypothyroid, 25 cases of type II diabetes, 25 cases of hypothyroid with type II diabetes, and 25 samples were taken as control. Result: The lipid profile levels were increased when compared with controls. There was a highstatistical significance p-value (<0.001) seen among three groups when compared with the control group. Conclusion: The current study concludes that there is a significant increase in the level of lipid profile in hypothyroid and type2 diabetes patients.Controlling the lipid profile levels through laboratory investigations is recommended in the current medical world to decrease the risk of cardiovascular disease.