Aims and objectives:To evaluate and compare results of totally tubeless Percutaneous Nephrolithotomy with standard percutaneous nephrolithotomy technique for management of renal and upper ureteric stones. Material and method: This prospective comparative study to evaluate safety and efficacy of the total tubeless PCNL in selected cases vs standard PCNL was undertaken in urology Department of MMIMSR,Mullana,Amballafrom March 2019 to February 2020. A total of 100 patients were included in the study and divided into two group each having 50 patients after randomization. Group 1(control group) is standard PCNL groupwhich involves placement of nephrostomy tube and DJ stent at the end of the procedure and group 2 (Test group) is Total tubeless PCNL groupin which insertion of both nephrostomy tube and double J stent are omitted.Results: The mean age of patients in group 1 and group 2 was 45.72±15.04 and 41.48±15.84 yearsrespectively. Number of males and females in group 1 was 34(68%) and 16 (32%) respectively while in group 2 was 33(66%) and 17(34%) respectively. The comparison between two groups for Mean age, Male/Female ratio,distribution of stones,Mean stone burden, duration of surgery, HB fall, stone clearance and complications were statistically insignificant ( P value >0.05).The comparison between two groups for post-operative pain score,postoperative analgesic requirement,hospital stay and return to normal activity were statistically significant (P value < 0.05). Conclusion:In conclusion both standard PCNL and Total tubeless PCNL are safe, effective and accepted procedures for primary management of renal and upper ureteric calculi. Total tubeless PCNL has favourable results in selected patients if stone burden is less than 3 cm in absence of significant residual stones, pelvicalyceal perforation and bleeding. Total tubeless PCNL has added benefit of decreased postoperative pain and lesser analgesia requirement.