Background: With 8.9% of all malignancies in both males and females, colorectal cancers rank third globally in terms of frequency and are the third largest cause of cancer-related mortality. The present study was conducted to assess adenocarcinoma in right hepatic flexure. Materials & Methods: 64 cases of adenocarcinoma in right hepatic flexureof both genders were enrolled. Both open and laparoscopic techniques were used. Parameters such as ASA score, TNM AJCC stage, number of lymph nodes harvested, length of hospital stay(LOS) in days, etc. were recorded. Results: Out of 64 patients, males were 40 and females were 24.ASA scoreI was seen in 4, II in 10, IIIin 32, and IV in 18 patients. TNM AJCC stageI was seen in 8, II in 34, and III in 22 patients. Method used was open in 26, and laparoscopic in 38. The number of lymph nodes harvestedwas <12lymph nodes in 41, and >12 lymph nodes in 23 patients. The length of hospital stay (LOS) in days in open method was 11.2 and in laparoscopic method was 5.4. R0 resection was done in 60 patients. The difference was significant (P< 0.05).Readmission within 30 days was seen in 7 (10.9%) and 30-day mortality was seen in 5 (7.8%). Conclusion: Maximum cases of adenocarcinoma of hepatic colon was seen among males. Readmission and mortality rate found to be high among patients.