Background:Hepatitis is inflammation of the liver, usually caused by viral infections (hepatitis A, B, C, etc.), excessive alcohol consumption, or autoimmune diseases. Cirrhosis is chronic liver damage leading to the formation of scar tissue, which can impair liver function. The present study was conducted to assess CRP value in patients with liver cirrhosis. Materials & Methods:74 patients with known cirrhosisof both genderswere divided into 2 groups. Patients in group I had compensated cirrhosis and group II haddecompensated cirrhosis.Patients were assessed by means of transabdominal ultrasound.Parameters such as etiology, IMC, IVC, serum creatinine, INR, bilirubin, CRP, and MELD was recorded. Results: In group I, males were 27 and females were 10 and in group II males were 22 and females were 15. Viral etiology was in 13 in group I and 12 in group II and non- viral etiology in 24 in group I and 25 in group II. The mean IMC was 0.002 in group I and 0.003 in group II. The mean inferior vena cava diameter was 21.4 in group I and 19.8 in group II. The mean serum creatinine level was 0.97 in group I and 1.3 in group II. INR was 1.45 in group I and 1.63 in group II. The bilirubin level was 1.36 in group I and 2.24 in group II. CRP level was 1.74 in group I and 1.57 in group II. MELD was 13.2 in group I and 17.1 in group II. The difference was significant (P< 0.05). Among survivors and dead, viral etiology was in 29% and 32% and non- viral etiology in 71% and 68%. The mean IMC was 0.002 and 0.003. The mean inferior vena cava diameter was 20.6 and 21.5. The mean serum creatinine level was 0.97 and 1.32. INR was 1.5 and 1.7. The bilirubin level was 1.7 and 2.3. CRP level was 1.06 and 1.35. MELD was 14.2 and 17.8 respectively. The difference was significant (P< 0.05). Conclusion: C-reactive protein represents a prognostic factor for cirrhosis evolution.The value of CRP influences the decompensation rates.