Introduction: The endogenous testosterone concentrations to be associated with more favourable cardiovascular profile, including higher HDL cholesterol and lower triglyceride concentrations, blood glucose, blood pressure and body mass index. The purpose of this study was to investigate the biological association between sex hormone profile and type 2 diabetes with dyslipidaemia in Indian men.Methodology: In this cohort study, total of 181 diabetic were enrolled as per WHO norms. As per their lipid profile, they were further divided into patients with dyslipidaemia and patients without dyslipidaemia. Along with clinic-demographical data, fasting blood glucose, Post-prandial blood glucose, HBA1c, insulin, lipid profile and Testosterone, LH, FSH were measured and compared. As per serum gonadal hormones assessment, LH and FSH showed significantly elevated levels in cases as compared to controls.Results:The majority of the patients in the case groups were aged between 31-40 years [82(45.30%)]. The FPG, HbA1c, total cholesterol, LDL, and triglycerides were significantly elevated in cases as compared to controls, except HDL and SHBG, showing non-significant differences. However, serum albumin (p<0.0001) and free testosterone (p<0.0001) were significantly lower in cases as compared to controls. The spearman correlation between Testosterone and different parameters, and all the correlations showed negative correlation.Conclusion:Significant association of dyslipidemia with hypogonadism in diabetic patients were observed. Low levels of testosterone are associated with visceral fat accumulation, metabolic syndrome, type 2 diabetes, increased inflammatory cytokines, hyperlipidemia and abnormalities of coagulation.