The third stage of labour is indeed the unforgiving stage of the labour and in it lurks more unheralded treachery than in both the other stages of labour combined.A normal casewithin a minute can become abnormal and successful delivery canswiftly turninto a disaster if neglected. An informed consent was taken from the patients who met the inclusion criteria. These women underwent a thorough general and systemic examination like cardiovascular system, respiratory system, per abdomen and per vaginal examination. The women were given either syntocinon(10U) intramuscular or per rectal misoprostol (600g) at the delivery of anterior shoulder of foetus. In misoprostol group, additional oxytocics in the form of 10 IU, oxytocin in intravenous drip was required in 10 patients& retained placenta occurred in 0 patient.Average blood loss was found to be 236.9±119.9ml. In Syntocinon group, additional oxytocics in the form of 10 IU, oxytocin in intravenous drip was required 7 patients and retained placenta occurred in 0 patient.Average amount of blood loss was found to be 160.5±127.5ml.