Background: With one of the fastest expanding populations in the world, India urgently needs to use safe and effective contraception. An optimal contraceptive should accommodate a person's social, medical, and personal needs; still, an optimal contraceptive should be safe, effective, have few adverse effects, and require less frequent administration. Aim: To evaluate the effectiveness of single dosage of depot medroxyprogesterone acetate (150 mg) IM (intramuscular) administered to patients immediately after abortion in achieving healthy timing and spacing of pregnancy. Methods: The present study was institutional cross-sectional study. Fifty-nine women undergoing abortion between the age group of 18 – 35 years who attends MTP clinic at Eden Hospital, Medical College and Hospital, Kolkata, West Bengal, India were included in the study. Study was conducted from July to December 2023. Statistical data were analysed by using Microsoft Excel and SPSS V.20. Results: Out of the 59 patients who were considered 63% were between age group of 20-25 years, 31% were in the age group of 26-30 years and rest 7% were in the age group of 31-35 years. Mean age was 24.32 years. Mean period of gestation was 10.19 weeks. Mean BMI was 21.33.Only 8% of the patients reported irregularity of menstruation before they were administered DMPA. In the study 37% of the mothers who were given DMPA complained about spotting during the first follow-up after 2 weeks of administration of DMPA.During the second follow-up after 3 months of administration of DMPA, 37% patients reported Amenorrhoea and another 49% of them reported spotting. Conclusion: The study can conclude that a single dose of 150 mg of DMPA is effective in preventing pregnancy for 6 months. This is cost effective and convenient for the patients. So, the usage of DMPA can be more in the developing nations.