Background: Depression is a prevalent mental health issue affecting individuals worldwide. Its association with obesity has been extensively studied, yet there is a need for further exploration to understand the nuances of this relationship.Materials and Methods: This comparative study aimed to investigate the prevalence of depression among obese and non-obese individuals. A sample of 200 participants, comprising 100 obese and 100 non-obese individuals, was recruited from diverse demographic backgroundsin duration of October 2021 to September 2023. Depression was assessed using standardized psychometric tools, and BMI (Body Mass Index) was calculated to categorize participants into obese and non-obese groups. Statistical analysis, including chi-square tests and logistic regression, was employed to examine the association between obesity and depression.Results: The prevalence of depression was found to be significantly higher among obese individuals (42.8%) compared to non-obese individuals (25.6%) (p < 0.001). Logistic regression analysis revealed that obesity was associated with a 2.34 times higher likelihood of experiencing depression (95% CI [1.78, 3.09], p < 0.001) after controlling for potential confounding factors. Additionally, obese individuals exhibited higher severity of depressive symptoms, with mean scores of 26.4 ± 4.5 on the depression scale compared to 18.9 ± 3.8 in non-obese individuals (p < 0.001).Conclusion: This study highlights a significant association between obesity and depression, with obese individuals demonstrating a higher prevalence and severity of depressive symptoms compared to their non-obese counterparts. These findings underscore the importance of addressing mental health concerns in obese populations and implementing integrated interventions that target both physical and psychological well-being.