Background: Acute cerebrovascular illness is now a treatable condition that warrants urgent specialist attention. Drug treatment and specialist care both influence survival and recovery. The present study was undertaken for assessing clinical and radiological profile of patients with acute cerebrovascular illness patients. Materials & Methods: A total of 50 patients with presence of acute cerebrovascular illness were enrolled. Complete demographic and clinical details of all the patients were obtained. Inclusion criteria for the present study included patients over 25 years of age with new onset stroke symptoms which were confirmed by radiological investigations. Clinical and radiological profiles of all the patients with acute cerebrovascular illness were analyzed. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Univariate analysis was done evaluation of level of significance. Results: While assessing the onset of stroke, it was seen that onset was insidious in nature in 72 percent of the patients while it was sudden in the remaining 28 percent of the patients. Involvement of left middle cerebral artery, right middle cerebral artery and internal cerebral artery was seen in 62 percent, 30 percent and 8 percent of the patients respectively. Left anterior circulation was involved in 66 percent of the patients while right anterior circulation was involved in 34 percent of the patients. Conclusion: From the above results, the authors conclude that the imaging protocol for stroke patients should combine plain CT, CT perfusion and CT angiography.