Introduction: Ischemic strokesuggested that platelet count was significantly lower in patients with ischemic stroke compared to healthy controls. Since platelets play principal roles in the patho physiology of the diseases, it is important to monitor platelets and their changes in various disease processes. Platelet indices are biomarkers of platelet activation. Aims: The aim of this investigation is to study the platelet indices such as MPV, PDW, PCT and PLCR in patients with Acute Ischemic stroke. The objective is to assess if any correlation exists between the studied platelet indices and Acute ischemic stroke. Materials and methods: One hundred consecutive patients with first ever acute ischemic stroke were recruited in this study. Non-contrast CT head was done to easily identify and differentiate acute ischemic stroke from haemorrhagic stroke. 5 ml venous peripheral blood collected in Ethylene diamine tetra acetic acid (EDTA) anti- coagulated tubes at the time of admission and processed within 2 hours of collection. The platelet indices were analyzed in whole blood using a blood cell counter. The severity of acute ischemic stroke patients was assessed using National Institute of Health Stroke Scale. Results: The mean age of total sample is 54.51 years with mean age of 54.54 years for males and 54.48 years for females. All the platelet indices studied were found to be increased with increase in severity of stroke and this increase was statistically significant for all platelet indices. Pearsons correlation showed that there is positive and high correlation between the mean values of platelet indices and NIHSS scores, and it is statistically significant. Conclusion: present study has shown that, higher the value of platelet indices, that severe is the acute ischemic stroke. Therefore, platelet indices can be used as positive predictor for acute ischemic stroke, as all the indices are well correlated with the severity of stroke.