Aim: To compare the effectiveness of scalp nerve block and morphine for providing transitional analgesia after remifentanil-based anesthesia in neurosurgery. Material and methods:A total of 100 patients, ranging in age from 20 to 72 years and classified as ASA I-III, who were scheduled to have an elective supratentorial craniotomy, were included in this research. The patients were allocated into two groups using a process of randomization utilizing sealed envelopes. Patients in the morphine group were administered morphine at a dosage of 0.1 mg per kilogram intravenously, diluted in 10 mL of normal saline, following the closure of the dura. Additionally, a scalp nerve block was performed using 0.9% normal saline as a placebo instead of the local anesthetic combination, as described in the Scalp Nerve Block section, at the conclusion of the operation. In the block group, patients were given 10 mL of 0.9% normal saline (placebo) intravenously following dural closure instead of morphine. The evaluation of pain after surgery was conducted at 1, 2, 4, 8, 12, 16, and 24 hours using a 10-point numerical rating scale. Results:There were a total of 100 patients included in the study, with 50 patients in each group. Group A is classified as a block group, whereas group B is classified as a morphine group. There were no discernible disparities in demographic and preoperative data across the groups. The intraoperative results were generally similar, except for the total minimum alveolar concentration-hours (MAC-h) of sevoflurane, which was higher in the morphine group. The statistical significance of this difference was due to a prolonged time of operation in the morphine group. The mean sevoflurane concentrations were 0.56 and 0.71 for the block and morphine groups, respectively. Patients in the morphine group had a higher incidence of nausea and vomiting at 12 and 24 hours after the surgery, but this difference did not reach statistical significance. There was no significant difference in the time it took to administer the first dosage of codeine between the two groups: 46 minutes for the block group and 31 minutes for the morphine group, with the median values. Conclusion: Ultimately, and in contrast to our first assumption, SNB seems to be comparable to morphine in terms of providing pain relief throughout the transition period in this group of patients. Further research is required to evaluate the advantages of alternative pain relief methods for managing transitional pain in individuals having intracranial surgery.