A seizure is a sudden, uncontrolled electrical disturbance in the brain. It can cause changes in behaviour, movements or feelings, and in level of consciousnessThe high incidence of epilepsy in children coupled with the need of long-term antiepileptic treatment could lead to development of metabolic complications at an early age and hence the risk of atherosclerosis. This study was conducted on 38 children in Department of Paediatrics at Soban Singh Jeena Government Institute of Medical Sciences and Research, Almora, Uttarakhand for one and a half year. Biochemical parameters like lipid profile, Lipoprotein a, liver enzymes along with relevant investigations were done before starting anti-epileptic monotherapy and were followed up after 6 months of treatment. Result shows among the antiepileptic drugs carbamazepine and phenytoin had statistically significant changes in lipid profile and lipoprotein (a) results while Phenobarbitone and Valproate didn’t show significant increase in lipid profile and lipoprotein (a) on follow up. The study shows several antiepileptic drugs with CYP450 enzyme inducers activity may cause significant rise in levels of lipids and lipoprotein a, hence causing a potent risk factor for atherosclerosis and cardiovascular complications in long term antiepileptic therapy.