Background:Diabetic neuropathy is a type of nerve damage that can occur in people with diabetes. The present study was conducted to compare the efficacy of gabapentin, and duloxetine in patients with painful diabetic peripheral neuropathy. Materials & Methods:74 patients with diabetic peripheral neuropathy of both genderswere divided into 2 groups of 37 each. Group I were given 300 mg/day gabapentin (GBP) and group II were given 20 mg/day duloxetine (DLX). The pain was assessed with visual analogue scale (VAS). The Sleep Interference Score (SIS), and adverse reactions were determined. Results: Group I had 20 males and 17 females and group II had 18 males and 19 females.Biothesiometry was mild in 6 and 8, moderate in 25 and 22 and severe in 6 and 7. Monofilament test was mild in 8 and 8, moderate in 19 and 20 and severe in 10 and 9 patients in group I and II respectively. The difference was non- significant (P> 0.05). Adverse reactions were in group I and group II were nausea/vomiting in 2 and 3, micturition in 1 and 0, dizziness in 0 and 1 and somnolence in 3 and 2 patients respectively. The difference was non- significant (P> 0.05). Conclusion: Monotherapy with GBP, and DLX provided clinically and subjectively meaningful pain relief in patients with DPNP.