Background: Instillation of buprenorphine in the epidural space during laminectomies for mitigating postoperative pain has been attempted in this study. Material and Methods: In the present study, forty patients of either sex scheduled to undergo lumbar or thoracic laminectomy were selected and divided into 20 in each group. The anaesthetic technique was standardized in both groups. At the end of the operation, before final closure, 0.3 mg diluted buprenorphine (study group) or saline (control group) (volume - 10 ml), was instilled in the epidural space under vision by the surgeon. All patients received diclofenac sodium 75 mg IV whenever they reported pain in the postoperative period. Pulse rate, mean arterial pressure (MAP), SpO2, respiratory rate, pain score and adverse effects (if any) were recorded before the operation and at 1, 2, 3, 4, 5, 6, 12, 18, and 24 hours postoperatively. The results were compared statistically between the study and the control group. Results: The pulse rate was consistently lower compared to the control group, indicating adequate analgesia in the study group. There was a significant difference in pain score in the buprenorphine group at 2, 3, 4, 5, 6, 12, 18th hours postoperatively when compared with placebo (p≤ 0.01). In the control group, the use of analgesics was more than in the study group.