Background: Thyroid diseases are, arguably, among the commonest endocrine disorders worldwide. The present study was conducted for assessing medication adherence among patients with thyroid dysfunction. Materials &Methods: A total of 100 patients diagnosed with Thyroid dysfunction were enrolled. Complete demographic and clinical details of all the patients were obtained. The suggested format was followed while recording the baseline data, which included test results, co-morbidities, co-medications, and patient demographics. The Morisky-8-item medication adherence questionnaire and the Brief Medication Adherence Questionnaire were used to measure medication adherence. The patients received appropriate medication counseling following the collection of baseline data. Finally; the results obtained were assessed and interpreted using statistical software. Results: A total of 100 patients with thyroid dysfunction were analyzed. Mean age of the patients was 49.2 years. Higher adherence to medication was seen in 33 percent of the patients while medium and low adherence was seen in 38 percent and 29 percent of the patients. Reasons for low/adherence included forgetfulness, financial problem, feeling cure and side-effects found to be present in 65.52 percent, 6.89 percent, 17.24 percent and 10.34 percent of the patients respectively. Conclusion: Patients with thyroid dysfunction are associated with low adherence. Hence; adequate motivational and education programs should be carried out time to time to motivate patients to take timely medicines.