Background:Millions of adults suffer with knee osteoarthritis (OA), which is characterized by severe pain, stiffness in the joints, and loss of function. The present study was conducted to compare PRP and corticosteroids in knee osteoarthritis. Materials & Methods:50 cases of knee osteoarthritis of both genderswere divided into 2 groups. Group I was PRP group (n = 25) who received an intra-articular injection of PRP (8 mL) and group II was corticosteroids (n = 25) group, in which patients received an intra-articular injection of triamcinolone acetonide (1 mL of 40 mg/mL) plus lidocaine (5 mL of 2%). The pain and function of the target knee were evaluated by the VAS, IKDC, and KSS scales at the baseline, 6 weeks, 28 weeks and 6 months after treatment. Results: Group I had 13 males and 12 females and group II had 11 males and 14 females. In group I and group II, KL degree II was seen among 7 and 9 and degree III among 18 and 16 patients. Left knee was involved in 8 and 10 patients and right knee in 17 and 15 patients. The difference was significant (P< 0.05).VAS at baselinein group I and group II was 6.4 and 6.1, at 6 weeks was 5.7 and 5.9, at 28 weeks was 4.2 and 4.8 and at 6 months was 2.5 and 3.6 respectively. IKDC at baseline was 36.4 and 30.5, at 6 weeks was 60.2 and 55.4, at 28 weeks was 65.3 and 48.6 and at 6 months was 62.1 and 38.4 respectively. KSS at baseline was 56.4 and 52.4, at 6 weeks was 60.2 and 67.4, at 28 weeks was 76.8 and 70.2 and at 6 months was 85.2 and 72.6 respectively. Conclusion: PRP intra-articular injection is safe, helps individuals with mild to moderate symptomatic knee OA, and improves knee function and short-term pain scores efficiently as compared to corticosteroids.