Background: Platelet count and PDW are the indicators of enhanced platelet activity and can be considered as potential biomarkers for diabetic microvascular complications like diabetic retinopathy. Aims and Objectives: To study platelet count and PDW in Type 2 diabetics with and without complications of diabetic retinopathy. Material and Methods: A cross sectional study was conducted on 75 Type 2 diabetes mellitus patients. Detailed clinical history regarding duration, and complications was taken. Platelet count and PDW were obtained using automated cell counter. Fasting blood glucose, HbA1c were also obtained. Diabetics were further categorized into patients with complications and without complications of diabetic retinopathy. Results: PDW was significantly (p=0.001) higher among patients with diabetic retinopathy than without retinopathy. Conclusion: PDW can be used as predictive marker of diabetic microvascular complication diabetic retinopathy. PDW is significantly raised in diabetic retinopathy. Platelet count can predict diabetic retinopathy correctly with a good sensitivity index.