Background: The present study was conducted for assessing pediatric patients with acquired demyelinating diseases in children. Materials &Methods: It was a retrospective study evaluating 40 patients of less than 15 years of age. Inclusion criteria for the present study included clinical, radiological, and immunological features of acquired demyelinating disorders. Complete clinical and demographic detail of the patients was obtained. A Performa was made and detailed medical history of all the subjects was recorded. All the results were recorded on a Microsoft excel sheet and were subjected to statistical analysis by using SPSS software. Univariate analysis was done for evaluation of the level of significance. Results: Data of a total of 40 subjects was analyzed. The mean age of the subjects was 12.9 years. Among these 40 subjects, ADEM, TM, NMI, MS and ON were found to be present in 62.5 percent, 15 percent, 12.5 percent, 7.5 percent and 2.5 percent of the patients respectively. Mean age of the subjects with ADEM, TM, NMI, MS and ON was found to be 7,6 years, 9.5 years, 9.9 years, 11.3 years and 12.8 years respectively. 21 subjects were males while the remaining were females. In majority of the cases, cerebral cortex was involved followed by thalamus and brainstem. Other areas to be involved included spin and optic nerve. Conclusion: Pediatric subjects having new, subacute focal neurological deficits in the absence of any traumatic history/metabolite disorder should be looked on with suspicion for having acquired CNS demyelination.