Background: This study was conducted to assess whether Physiologic Breakdown Mask Significant Pathology in Endometrial Biopsies. Material and methods: 200 patients who were diagnosed with either "menstrual" or "extensive breakdown" were included in this study. Patients in the "extensive breakdown" and "menstrual" groups were removed if they were younger than 40 or 50 years old, respectively, in order to increase the population's likelihood of having substantial endometrial disease. The original hematoxylin-eosin-stained histologic slides from the initial and follow-up biopsies, as well as the reports, were examined by the authors. If the pathology follow-up revealed cancer or hyperplasia of any kind, it was deemed noteworthy. The 6-month period was chosen to make sure that the pathology seen on the second test was not anything that was overlooked on the biopsy specimen that was initially presented, but rather an indication of a different process. In total, 100 instances were selected based on their meeting of inclusion criteria.Results: In this study, out of 100 subjects, 21 belonged to the age group of 40 years, 23 belonged to the 41-45 years group, 36 subjects aged between 46-50 years and the remaining 20 belonged to the age group of 51-55 years. The majority of the diagnoses made on the initial biopsy specimens were descriptive: menstrual (56 cases), secretory, inactive, or proliferative (23 cases), and altered/disordered endometrium (2 cases) were all described. Nineteen women had specific benign diagnoses, such as nine endometrial polyps, five leiomyomas, and five chronic endometritis cases. Conclusion: Extensive breakdown or menstrual-pattern endometrium might conceal some other benign conditions, although cancer is rarely concealed by these conditions.