Background:Proximal humerus fractures are common and debilitating injuries and incidence of them are increasing especially in elderly. Treatment of unstable, displaced, and comminuted fractures of the proximal humerus remains challenging. This present study is aimed to assess the functional outcome in proximal humerus fractures treated surgically with PHILOS (Proximal Humerus Internal Locking System) plate and percutaneous K-wire fixation in the indicated group of patients. Methods:This is a prospective study, period from December 2019 to August 2021, and a minimum of 50 sites of proximal humerus fractures were attended in the casualty and OPDwere evaluated clinically and radiographically. Results:Functional assessment using NEER’s score was found to be significantly more in group A subjects as compared to group B subjects at 6 weeks, 12 weeks and 6 months. At 6th week, TRU score was found to be significantly more in Group B subjects as compared to Group A subjects. Conclusions:In the present study it is concluded that PHILOS plate provide stable fixation even in comminuted multi-fragmented osteoporotic proximal humerus fracture with advantage of anatomical reduction and early rehabilitation.