Background:Lower respiratory tract infections (LRTI) are the most common bacterial infections among patients in neurological intensive care units (NICUs). Different scenarios might be identified by physicians dealing with nosocomial respiratory infections.The epidemiological and clinical evaluation of LRTIs acquired in the hospital setting remains a topic of outstanding relevance. Hence; the present study was conducted for evaluating antimicrobial resistance and antibiotic susceptibility pattern in patients with lower respiratory tract infection in intensive care unit.Materials &Methods: A total of 100 patients admitted to ICU were enrolled. Only those patients were enrolled which developed LRTI among ICU patients were enrolled. Complete demographic and clinical details of all the patients were obtained. O Clinicopathological Indicator score (CPI score) was obtained on day 1 and day 2. Sputum samples were collected from all the patients. Blood agar and MacConkey agar were used for quantitative cultures and >106 CFU/ml on quantitative culture was considered pathological. Blood culture was done in patients with suspected bacteremia and sepsis. Antibiotic susceptibility pattern was evaluated.Results:Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii and Streptococcus pneumonia was detected in 20 percent, 18 percent, 10 percent, 38 percent and 14 percent of the patients respectively.Amoxicillin and Ceftazidime were the most commonly prescribed antibiotics. Klebsiella pneumonia was susceptible to amikacin and colistin. Pseudomonas aeruginosa was susceptible to amikacin, Ceftazidime, cotrimoxazole and colistin. Staphylococcus aureus was susceptible to Linezolid and Colistin. Acinetobacter baumannii was susceptible to cotrimoxazole and colistin. Conclusion: Acinetobacter baumannii was the most common microorganism isolated in the present study highlighting the need for antibiogram for each ICU.