Aim:This study aims to evaluate the role of antibiotics in the management of acute appendicitis and to assess whether appendectomy retains its status as the gold standard of care. Materials & Methods:A total of 40 patients within the age range of 18 to 60 years were enrolled. Only those patients were included which had a clinical suspicion of uncomplicated acute appendicitis. CT of the abdomen The prophylactic antibiotics were given around half an hour before to the incision. During their hospital stay, patient outcomes were evaluated, and a visual analog scale (VAS) was used to measure pain. Resolution of acute appendicitis, which led to hospital release without the need for surgery and no recurrence, was the main outcome goal for patients in the antibiotic group. Results:Mean age of the patients of the surgical group and antibiotic group was 38.3 years and 37.1 years respectively. Overall complications rate and incidence of surgical site infection was higher in surgical group in comparison to antibiotic group. Also mean VAS at follow-up was higher in surgical group. Conclusion:For patients with uncomplicated appendicitis, antibiotics are a safer option.