Introduction: Schizophrenia is a chronic mental illness.Care givers of these patients are usually family members who often experience high degree of burden, lack of social support and stigma. Aims: The aim of this study ‎was to assess the family burden reported by ‎caregivers of Patients with ‎schizophrenia.‎ Materials and methods: A cross sectional study was done in 100 family members of patients with schizophrenia attending a tertiary care hospital. Data was collected using semi structured questionnaire and family burden interview schedule (FBIS) and general health questionnaire(GHQ). Results: Most of the patients are males, single, illiterates and unemployed. Caregivers are females, married, literates and employed.Relationship of patient with caregivers are parents in most of the families.Based on GHQ score 32 caregivers experienced mild distressand 55 caregivers experienced severe distress. Financial burden, Disruption of family's routine activities and physical health of caregiver is increasing the burden on the family. Number of admissions in 1 year =>3, Caregiver's gender and Patients age were significant Predictors of family burden. Conclusion: There is a requirement for economic support and early intervention to reduce growing incidence of mental health problems in caregivers of schizophrenia patients.